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Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

In Arabidopsis, two genes each encode dual-targeted glutathione reductases (GR), and this is sufficient to explain the presence of GR activity in the chloroplasts, mitochondria, cytosol, and peroxisomes (Chew et al., K M value for NADPH below 10 M (Edwards et al., GR1 , encoding the cytosol/peroxisome enzymes, causes only moderate GSSG accumulation in leaf tissue, an observation explained by the existence of an auxiliary GSSG-reducing activity ensured by cytosolic NADPH-thioredoxin (TRX) systems (Marty et al., In contrast to GSSG reduction, the reactions that are most important in converting GSH to GSSG are less clear and, potentially, more complex

Agric Biol Chem 52:27532762 Ohtake Y, Watanabe K, Tezuka H, Ogata T, Yabuuchi S, Murata K, Kimura A (1989) Expression of glutathione synthetase gene of Escherichia coli B in Saccharomyces cerevisiae

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