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Pro-inflammatory adipokines (IL-6, TNF- and monocyte chemoattractant protein-1) and leptin, associated with the preservation of obesity, are raised during obesity (Reference Eskandari, Hooshmand Moghadam and Bagheri9)

Monocytes, macrophages, and T cells produce pro-inflammatory cytokines, including tumor necrosis factor- (TNF-), interleukin-6 (IL-6), IL-1, IL-8, and IL-17, which exacerbate inflammation, IR, and fibrosis, which accelerate the development of NASH

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Intramuscular injections can be administered in the arm, thigh, or buttocks