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This would be particularly attractive in combination with inhibitors of MSH biosynthesis to combat tuberculosis (TB) disease since MshB inhibitors are successfully applied in the clinical practice 54, 55

Defective fission-fusion dynamics, impaired mitophagic clearance, suppressed biogenesis, and disrupted proteostasis converge to produce bioenergetic failure, pathological ROS overproduction, calcium dyshomeostasis, and resistance to apoptosis, thereby transforming mitochondria from cellular powerhouses into drivers of lesion persistence and inflammation

What you should do You can continue to take both medications as prescribed by your doctor

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