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Bringing any drug through Phase II and Phase III to regulatory approval costs hundreds of millions

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The dosing ranges most commonly referenced in preclinical literature and researcher communities are 250500 mcg (micrograms) administered once to twice daily

The blots were developed using Radiance Plus chemiluminescent substrate (Azure Biosystems, Dublin, CA, USA), and the signals were quantified using the ImageQuant LAS-4000 mini-Imager (GE Healthcare, Chicago, IL, USA)