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Diagnosing and Testing for Vitamin B12 Deficiency in the UK In the UK, diagnosis of vitamin B12 deficiency follows guidance from the British Society for Haematology (BSH) and NICE , emphasising a combination of clinical assessment and laboratory investigation

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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

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