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The biologically active forms of selenium include total selenium concent, specific chemical species (such as SeMet, SeCys, selenocysteine (SeCys2), Se-methylselenocysteine (SeMeSeCys), selenate, and selenite), as well as functional selenoproteins like glutathione peroxidase 3 (GPX3) and SELENOP glutathione peroxidase (GPx) enzymatic activity 4,6

According to theoretical modeling studies, however, the pKa of Sec does not alone account for the catalytic difference between Sec and Cys-substituted enzymes

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Antioxidant regulation improving resistance to oxidative stress