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Based on preclinical data demonstrating substantial MPNST shrinkage in mice treated with a combination of MEK and mTOR inhibitors, SARC031 is a trial of the MEK inhibitor selumetinib in combination with the mTOR inhibitor sirolimus for patients with unresectable or metastatic MPNST

The opposite result was obtained for GSTE2-2, indicating these two GSTs play an important role in gaining resistance to DDT via conjugation and peroxidase activity, respectively [49]