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doi: 10.1016/j.molcel.2011.08.018 31 CirilloFCatellaniCLazzeroniPSartoriCStreetME

T.SchindlerF.OkawaraM.et al

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Notably, taken together the upregulated NOS activity following BH4 supplementation with sepiapterin, and the decrease in superoxide and NT suggests an improvement in the tissue NO:O 2 ratio and lower nitro-oxidative stress