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6 Studies have shown that more than 50% of contact lens wearers have tried artificial tears to relieve their discomfort

Troseid M et al (2015) Microbiota-dependent metabolite trimethylamine- N -oxide is associated with disease severity and survival of patients with chronic heart failure

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The diagnostic approach, therefore, should follow the path of those neurodegenerative diseases, like Alzheimers disease (AD) for example, and less of toward disease with simple diagnostic cut-off using blood-based biomarker, such as diabetes mellitus, wherein diagnostic confirmation, monitoring treatment response, as well as prognostication can be done using a clear cut-off point of plasma glucose levels