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By using mice deficient in glutamate-cysteine ligase (GCL) in keratinocytes, the authors found that GSH deficiency results in more DNA damage and cell death, suggesting a crucial role for the antioxidant capacity in skin integrity maintenance [93]

BindingDB: a web-accessible database of experimentally determined proteinligand binding affinities

An established concept is that PENs can serve as haptens to induce IgE through irreversibly forming drug-protein conjugates in vivo 2,9

These findings support the rationale for combining cancer vaccines with immune checkpoint blockade to overcome the immunosuppressive tumor microenvironment and generate durable anti-tumor responses [248]