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This mechanism is also evident in currently employed anticancer therapies [5]

Am J Obstet Gynecol 192(2):6339 Tsutsumi K, Kotegawa T, Matsuki S, Tanaka Y, Ishii Y, Kodama Y et al (2001) The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans

In addition to the eleven cohort studies from the USA and Europe, one cohort study in Australia also provided results on several different cancer end-points: The MCCS used an FFQ to quantify the frequency of consumption of diet soft drinks at baseline in 19901994, which was after the approval of aspartame use in foods and drinks in Australia in 1986 (Hodge et al., 2018)

These changes were not due to the limitations of the Langendorff mouse heart model as we found comparable results on analysing in vivo ischaemia in the heart using the left anterior artery, descending (LAD) occlusion model (Supplementary Fig