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10.1016/j.neuint.2007.06.005 Neurochem

Seeding accelerates aggregation and is a prerequisite for prion-like spreading

PLoS ONE 11 , e0148684 (2016)

Future challenges to overcome in the development of NRF2 activators as disease modifying treatments include the establishment of compounds with good pharmacokinetic and pharmacodynamic profiles that ensure sustained, brain wide NRF2 activation