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The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository (proteomexchange.org) with the data set identifier PXD036803 ( The mass spectrometry metabolomics data (2 data sets from kidney and plasma, respectively) have been deposited to the Zenodo repository ( All reagents, softwares, mouse lines, and data repository information are available in Supplemental Table 7

Exchange is driven by the out-to-in Cl--concentration gradient created by the ATP-dependent, secretin-activated channel, cystic fibrosis transmembrane regulator (CFTR)

In the phase 1/2 COMPOSE study, pegtibatinase demonstrated promising tolerability and a safety profile with only two incidents of mild injection site urticaria that resolved upon temporary dose interruption and subsequent dose titration

This result was consistent with the studies conducted for this issue, [,,] where they designated the age-related decrease in GSH levels due to the increased rate of chronic diseases such as hypertension and diabetes