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Increased metformin exposure was hypothesized to be associated with lower levels of B12 and more severe peripheral neuropathy [51]

Brain imaging as well as blood and urine tests can help to determine whether a patient has PD or another similar disorder

Table 1) were prepared in 100 mM sodium phosphate buffer (pH 6.5) supplemented with 5 mM perdeuterated DTT and 0.5 mM EDTA in H 2 O/ 2 H 2 O (9/1) or 2 H 2 O