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In Regland et al.s study, all patients had normal serum levels of vitamin B12 and homocysteine, however, levels of B12 in CSF correlated significantly with fatigue and items of a psychopathological scale [16]

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[6] [7] For patients with neurological symptoms, hydroxocobalamin 1mg IM is given on alternate days until no further improvement, followed by maintenance injections of 1mg every two to three months