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Targeting oxidative phosphorylation-proteasome activity in extracellular detached cells promotes anoikis and inhibits metastasis

XJZ reduced mucosal damage, increased ZO-1 and occludin expression, decreased epithelial cell apoptosis, decreased the expression of autophagy-related proteins LC3 and beclin1, increased the expression of p62, activated the PI3K/AKT/mTOR/ULK1 (ser757) signaling pathway, inhibited AMPK/ULK1 (ser317) signaling pathway, antagonized the imbalance of redox homeostasis, and protected the gastric mucosa [83]

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It has been efficient in increasing the TDDs with varying molecular weights including small (fentanyl, orcalcein) to high molecular weight drugs weighing up to 40 kDa