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Conclusion Hepatic fibrosis is a complex dynamic process which is mediated by death of hepatocytes and activation of HSCs

Translation of these regenerative and network-based therapies into clinical practice will require careful calibration

Additionally, this interaction can stimulate the secretion of innate immune cells to lyse sufficiently opsonized targets, a phenomenon known as antibody-dependent cellular cytotoxicity [ADCC] [184]

Here, increased endothelin and decreased NO (a vasoconstrictor and vasodilator, respectively) levels induce cellular swelling, which in turn leads to sinusoidal narrowing [30]