can glutathione whiten groin as a skin whitening agent: Facts, myths, evidence and controversies Glutathione Injections For Skin Whitening:

Yu, M.K

The use of the TCM formulas should be based on the treatment with syndrome differentiation, which is one of the features of TCM theoretical system

In this protective role, ATF4 drives the expression of the chaperone heat shock protein family A (Hsp70) member 5 (HSPA5), which in turn stabilizes and enhances the activity of GPX4, thereby inhibiting ferroptotic cell death ( In ferroptosis resistant melanoma cells, CHAC1 was shown to be upregulated by NRF2 independent from ER stress signaling alongside the Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) capable of degrading lipid radicals ( CHAC1 , most melanoma cell lines appear to be resistant against ferroptosis

Nat Rev Mol Cell Biol 23(10):663679