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Description

In CRC, valosin-containing protein (VCP) upregulates CPT1 expression by accelerating HDAC1 degradation to enhance FAO and tumor progression (120), while CPT1A-mediated FAO suppresses anoikis to facilitate metastasis (121)

The use of single electron radical chemistry provides superior selectivity in the presence of unprotected amino acid functional groups, which can include both nucleophilic and electrophilic groups prone to side reactions in two-electron approaches

J Endocrinol (2010) 205(3):2717

TNF- acts through several mechanisms, directly affecting neuronal function, reducing 5-HT synthesis, impairing gut barrier integrity, and promoting intestinal muscularis inflammation