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Accordingly, Nasca and coworkers found that chronic unpredictable stress causes large reductions in hippocampal mGlu2 receptors exclusively in mice that are not resilient to stress, and that mice lacking mGlu2 receptors are more susceptible to stress [138]

Thus, in the well-fed state, insulin enhances the carbon flux through the pentose phosphate pathway, increasing NADPH production Note: insulin also promotes fatty acid synthesis, which depends on a continuous supply of NADPH