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doi: 10.1016/j.bbagrm.2012.06.005 71 EmeryACPshenichkinSTakoudjouGRGrajkowskaEWolfeBBWroblewskiJT

These observations suggest that (i) CopA functions as the primary copper efflux system, (ii) CopA alone may be insufficient under high copper stress conditions ( 8 mM), and (iii) CzcCBA may function as a secondary or auxiliary efflux system under extreme copper loads