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Cell membranes have transferrin receptors (TFR)

Because of the enhanced bioavailability and decreased clearance of the nanoparticles, it is thought that a larger aspect ratio of the particles corresponds with increased cytotoxicity

The greatest diagnostic and, consequently, therapeutic problems result from the fact that the Ixodes ricinus tick can transmit several pathogens simultaneously, causing co-infections, which may lead to nonspecific symptoms and significantly complicate the diagnosis and treatment of patients 2

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