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35,36 Amino Acids and Cortisol, Norepinephrine L-lysine and L-arginine: L-lysine and L-arginine given orally were shown effective at reducing chronic anxiety in a double-blind placebo-controlled study published in 2007 by Smriga et al in the Journal of Biomedical Research

Hamelet J, Demuth K, Dairou J, Ledru A, Paul JL, Dupret JM, Delabar JM, Rodrigues-Lima F, Janel N: Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice

High-level TGF signalling is characteristic of many stroma-rich tumour types, including CMS4 CRC [3] and is a major metastasis-promoting signalling pathway in late-stage CRC [45]

In this review, we summarize the effective role of flavonoids in the treatment of liver disease (in Figure 3), and provide insights into their mechanism of action and targets