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Most strikingly, analysis of the relative abundance of these metabolites showed extracellular accumulation of several aromatic amino acids and weak acids (e.g., dicarboxylic acids, ketones/keto-acids, and hydroxy fatty acids) in the gsh2 mutant and a significantly depleted intracellular amino acid content (Fig

1 Introduction Viral pneumoniaprincipally caused by influenza viruses, coronaviruses, and related pathogensis an inflammatory condition of the lung in which direct viral injury to the alveolar epithelium, coupled with an exaggerated host immune response, leads to impaired gas exchange and, in severe cases, multi-organ failure (Ruuskanen et al., 2011