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by modulating the antioxidant defense and glyoxalase systems

There is some controversy, however, regarding nicotine: there is a case report of nicotine actually helping alleviate symptoms in a patient (Oksenberg 2009), and another case report of exacerbation of RLS symptoms following smoking cessation (Juergens 2008)

Cytogenet Cell Genet 92 : 122126

Abbreviations 3'UTR: 3-untranslated region 5hmC: 5-hydroxymethylcytosine 5mC: 5-methylcytosine A2780: Ovarian cancer cell line A2780 ALDH1A3: Acetaldehyde dehydrogenase 1 family member A3 ANXA9: Annexin A9 ASOs: Antisense oligonucleotides ATG14: Autophagy-related gene 14 AUC: Area Under the Curve AURKA: Aurora Kinase A AZA: Azacitidine BCL2: B-cell lymphoma-2 BCL2L2: BCL2-like 2 BETi: BET inhibitors BIRC3: Baculoviral IAP repeat-containing 3 BIRC5: Baculoviral IAP repeat-containing 5 BV: Bevacizumab C/EBP: CCAAT/enhancer-binding protein CASC10: Cancer Susceptibility Candidate 10 CASR: Calcium-sensing receptor CBP: CREB-binding protein CCAT1: Colorectal Cancer Associated Transcript 1 CD44: Cluster of Differentiation 44 CDDP: Cisplatin ceRNA: competing endogenous RNAs CI: Confidence Interval CICs: Cancer-initiating cells CircRNA: circular RNAs CRNDE: Colorectal Neoplasia Differentially Expressed CSCs: Cancer stem cells CSF-1: Colony-stimulating factor 1 CSK: C-terminal Src kinase ctDNA: Circulating tumor DNA DDR: DNA damage response DDR1: Discoidin Domain Receptor 1 DDX3X: Dead-box helicase 3 X-linked DDX5: Dead-box helicase 5 DEC: Decitabine DLT: Dose-Limiting Toxicity DNMTs: DNA methyltransferases EMT: Epithelialmesenchymal transition ENG: Endoglin EOC: Epithelial ovarian cancer EVs: Extracellular vesicles EZH2: Enhancer of Zeste Homolog 2 FBXL10: F-Box and Leucine-Rich Repeat Protein 10 FBXO32: F-box protein 32 FOSL2: FOS-Like 2 FOXP1: Forkhead box protein 1 FZD7: Frizzled Class Receptor 7 GAS5: Growth arrest-specific 7 GC: Gemcitabine + Carboplatin GSH: Glutathione GSK3B: Glycogen synthase kinase 3 GST: Glutathione transferases GSTP1: Glutathione S-transferase P1 HAT: Histone acetyltransferase HDAC: Histone deacetylase HDACi: HDAC inhibitors HDMTs: Histone demethylases HGSC: High-grade serous ovarian cancer HMT: Histone methyltransferases HOTAIR: HOX Transcript Antisense Intergenic RNA HOTTIP: HOXA Transcript at the Distal Tip HR: Homologous recombination HRD: Homologous recombination deficiency HRK: Hazard Ratio IC: Half-maximal Inhibitory Concentration IGF2BP1: Insulin-like growth factor 2 mRNA-binding protein 1 IGROV1: Ovarian cancer cell line IGROV1 JAK2: Janus Kinase 2 JHDM2A: JmjC-domain-containing histone demethylase 2 A KDM3A: Lysine demethylase 3 A KLF4: Krppel-like factor 4 LncRNA: long non-coding RNAs LNP: Lipid Nanoparticles M6A: N6-methyladenosine MAFG: MAF BZIP Transcription Factor G MAL: Myelin and Lymphocyte protein MALAT1: Metastasis-Associated Lung Adenocarcinoma Transcript 1 MAPK: Mitogen-Activated Protein Kinase METTL3: Methyltransferase-like 3 MiRNA: microRNAs MMP3: Matrix Metalloproteinase 3 mTOR: Mammalian Target of Rapamycin NAV3: Neuron Navigator 3 NF-B: Nuclear Factor-Kappa B NRF2: Nuclear factor-erythroid 2-related factor 2 OC: Ovarian cancer ORR: Objective Response Rate OS: Overall Survival PARP: The Poly (ADP-ribose) polymerase PARPi: PARP inhibitors PAX9: Paired box gene 9 PDX: Patient-Derived Xenograft PFS: Progression-Free Survival PI3K: Phosphoinositide 3-Kinase PTEN: Phosphatase and tensin homolog deleted on chromosome 10 RAD51: RAD51 recombinase STAT3: Signal Transducer and Activator of Transcription 3 SKOV3: Ovarian cancer cell line SKOV3 SLC31A1: Solute Carrier Family 31 Member 1 SRSF1: Serine-Rich Splicing Factor 1 TGF-: Transforming Growth Factor Beta TMEM88: Transmembrane Protein 88 TMIGD2: Transmembrane and Immunoglobulin Domain Containing 2 TP: Toosendanin UCA1: Urothelial carcinoma-associated 1 Wnt/-catenin: Wnt/-catenin pathway XIAP: X-linked inhibitor of apoptosis protein YAP1: Yes-Associated Protein 1 YBX1: Y-box binding protein-1 YES1: YES proto-oncogene 1 YTHDF1: YTH N6-methyladenosine RNA Binding Protein 1 YTHDF2: YTH (YT521-B homology) domain 2 ZEB2: Zinc Finger E-Box Binding Homeobox 2 References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al