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Effects of gut microbes on nutrient absorption and energy regulation

Here, we discuss whether the loss of nutrients associated with disc degeneration limits the effectiveness of biologic approaches, and indicate that this neglected problem requires investigation if clinical application of such therapies is to succeed

long-term use associated with osteoporosis, adrenal suppression (code separately) Immunomodulators: Azathioprine (AZA), 6-mercaptopurine (6-MP), methotrexate for maintenance of remission