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The Pontryagins Minimum Principle and Hamiltonian equations are used to derive the optimality conditions

They are also responsible for the development of male secondary sexual characteristics (androgenic effect) ( Uncontrolled use of substances from the AAS group for non-medical purposes is associated with a high risk of adverse effects on the liver and the reproductive, musculoskeletal, cardiovascular, and central nervous systems

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Viscosupplementation isn't suggested for individuals who have severe, end-stage, or bone-on-bone arthritis