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Bioinformatics 30 , 13631369, (2014)

GeroScience 47, 39273939

Depression ranges from everyday situational depression to major depressive disorder, characterized by profound hopelessness, helplessness, and biological symptoms such as sleep disorders and anhedonia and can be mimicked by symptoms of cirrhosis like HE and delirium, necessitating careful psychiatric differential diagnoses

The studies demonstrated the importance of not only the amino acid residue isoleucine 253 (I253) in the IgG Fc, but also of histidines (including H310 and H435), the pKa of which results in protonation/deprotonation in the endosomal pH range