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Description

Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system

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Fast liquid chromatography (FPLC) analysis of nephrotic serum revealed a decreased 150 kDA IGFBP ternary complex due to reduced intact IGFBP-3, whereas IGFBP-3 low molecular weight fragments were markedly increased, suggesting increased proteolytic degradation of IGFBP-3