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Most of PD cases are sporadic and only a minor subset of overall PD cases is associated to be familial 4,5

Its also important to consider the psychological and lifestyle aspect

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Moreover, abnormal electrophysiological parameters arising due to the activity of ion channels, receptors, and transporters were noted in astrocytes isolated from patients with mesial temporal lobe epilepsy and associated sclerosis (Verkhratsky et al., 2019a,b)