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Studies indicate that A1AT therapy can lead to a reduction in systemic inflammation, as measured by lower CRP levels, thus potentially decreasing the overall inflammatory burden on the lungs (68) Moreover, the reduction in inflammatory markers can also be indicative of the therapys effectiveness in mitigating the proteolytic damage caused by neutrophil elastase, which is typically unopposed in AATD patients due to low A1AT levels

Conditions persisting six months or longer have established dysfunctional tissue patterns that take longer to remodel

The questions to achieve the objective of the SR ( Table 1 ) were formulated based on Population Intervention Comparison Results (PICOS) criteria ( Table 2 )

Language development is frequently affected, encompassing delayed acquisition and severe impairments in expressive abilities