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5 The nucleus: A genome-associated dynamic network for precision targeted strategies 5.1 Structure of nucleus The nucleus, the living hallmark of eukaryotic cells, is the housekeeper of the majority genomes, playing a crucial role in maintaining the stability of genetic materials and regulating osteogenesis and metabolism (200)

[ 18 ] also showed no distinct adverse effects of the substance

However, cisplatin treatment is associated with toxic side effects and tumour cells can develop resistance to its effects thereby limiting its efficacy (Florea and Bsselberg 2011)

Concurrent mitochondrial dysfunction reduces ATP availability, potentially weakening the Na+-dependent driving force and regulatory phosphorylation processes required for OCTN2 membrane localization [113]