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Explanation of key changes on 2022 WADA prohibited list

110,111 Non-Membrane Disrupting Mechanisms of AMPs Although the electrostatic interaction with tumor cell membrane and further disrupting action is the key of AMPs to kill the tumor cells, certain AMPs are accompanied by other mechanisms, such as inhibiting tumor DNA synthesis, destroying tumor cytoskeleton, inhibiting tumor angiogenesis, destroying tumor mitochondria, inducing tumor cell apoptosis or necrosis, and regulating immunity, as shown in Figure 3

Quercetin inhibits ferroptosis by activating the NRF2/HO-1 pathway in models of diabetic nephropathy, a mechanism that is potentially relevant to DACI (72)

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