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Antonoff MB, Ragalie W, Correa AM, Spicer JD, Sepesi B, Roth JA, Walsh GL, WlL H, Swisher SG, Rice DC , Vaporciyan AA, Mehran RJ

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In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability