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CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation

For example, HDIVC (50 mg/kg every 6 h for 96 h) failed to improve outcomes in vasopressor-treated septic ICU patients, instead increasing death or persistent organ dysfunction without secondary benefits (Lamontagne et al., 2022)

At d31, a signal was detected in additional organs, and dissection revealed metastases in the liver, adrenal glands, and ovary outside of the lungs at this time