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This finding related to combination therapy concurs with the study by Shankar and colleagues, which showed that patients who received combination therapy with a CTLA-4 inhibitor and PD-1/PD-L1 inhibitor had an increased risk for multisystem immune-related adverse events

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It is typically administered via injection, subcutaneously under the skin of the stomach once a day with a 30g inulin needle, after mixing the lyophilized powder with sterile bacteriostatic water

Also, an enhanced selection criterion to identify patients with advanced-stage cancers who will or will not benefit from ICI agents is essential, and the need to involve early primary palliative care for the potential non-responders