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Hyperglycemia, AGEs, mitochondrial oxidative stress and ultrafiltration cytokines act on renal tubular cells and trigger multiple cellular pathways such as PKC-, -, and -, NF-B, P38 and ERK1/2 pathways, further exacerbating renal tubular cell hypertrophy, apoptosis, and accumulation of tubulointerstitial inflammatory factors (51)

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A 12-h day/night cycle allows the animals to maintain a normal circadian rhythm, with free access to food and water

Sterile Water Solution for Laboratory Applications This sterile solution is frequently selected by laboratories and researchers that require reliable dilution support for peptides and other compounds