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In PD models, Stat1 ablation alleviated -synuclein fibril-induced suppression of microglial ULK1 transcription and autophagy, which is consistent with the mechanism whereby -synuclein disrupts microglial autophagy through STAT1-dependent repression of ULK1 expression

10.1016/j.tins.2008.07.003 13 BrintonR

It supports collagen production, improves skin elasticity, reduces inflammation, and enhances wound healing

The first such therapies were available in the early 2000s, with bevacizumab approved in 2004 for colorectal cancer which was soon expanded to other types of cancer treatment including lung, glioblastoma multiforme, ovarian, renal, and metastatic breast cancer (240, 241)