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By reducing the anionic surface charge of the endothelial glycocalyx, MPO facilitates neutrophil recruitment to sites of infection/inflammation, independent of its classic catalytic function [313]

A lack of clarity about who is responsible for implementation, funding, or monitoring can derail even the most promising projects

In parallel, a failure in the antioxidant mechanism would occur, disrupting cell homeostasis and culminating in cell damage.52 Melanocytes cultured from unaffected areas in patients with vitiligo have a greater susceptibility to oxidative stress than from controls without vitiligo, demonstrating an overall susceptibility of the patient with vitiligo to oxidative damage.53 There is an increase in the superoxide dismutase enzyme (responsible for degrading the O2 radical into H2O2 and O2), an increase in lipid peroxidation (secondary to OS), in addition to a reduction in the catalase enzyme (which converts H2O2 into H2O and O2) in vitiligo

This is called melasma or the "mask of pregnancy." It usually shows up on the cheeks, forehead, or upper lip