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For example, the clearance of medium and large molecules such as 2-m (11,800 Da), myoglobin (17,200 Da) or kappa (22,500 Da) and lambda (45,000 Da) light chains occurs exclusively by adsorption, since the low permeability of the membrane used during the diffusive phase prevents their elimination at this level.63 To increase the scavenging capacity of HFR, the first step has been to replace this low diffusive membrane with a high permeability one, giving rise to the so-called high flux HFR (HFR-H).46 The available preliminary results obtained with this change, pending final publication, are very interesting as they allow increasing the elimination of medium and high molecular weight uremic toxins, with an improvement in other biological parameters related to inflammation, oxidative stress and senescence

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms