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de Moura LD, Ribeiro LN, de Carvalho FV, Rodrigues da Silva GH, Lima Fernandes PC, Brunetto SQ, et al

In these patients, mixed agonist/antagonist and partial agonist analgesics may reduce the analgesic effect and/or precipitate withdrawal symptoms [see PRECAUTIONS

When mitochondria slow down (from age, chronic stress, poor diet, or being sedentary), your whole metabolism slows with them

Tonic GABA release in the dentate gyrus disrupts synaptic plasticity by persistently activating extrasynaptic GABA A and GABA B receptors, thereby diminishing excitatory neurotransmission and long-term potentiation, favoring synaptic depression and memory impairment 534