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Methods: A descriptive observational study was conducted at Bachmai Stroke Center between December 1, 2023, and August 31, 2024, enrolling minor ischemic stroke patients (NIHSS scores 5 and items 1a, 1b, and 1c on the NIHSS scale = 0) hospitalized within 24 hours of symptom onset and had END (defined as a rise of 2 points in the NIHSS score during the first 72 hours after admission)

If required, gentle heating or sonication may be used to support dissolution

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