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Since A does not accumulate in any of these apoE isoform transgenic mouse models, these data strongly suggest an A-independent role of apoE4 in causing neuronal and behavioral deficits in vivo

doi: 10.1002/vms3.83 10 HowickKGriffinBTCryanJFSchellekensH

Iron-induced formation of ROS causes oxidation and oligomerization of Tom20, leading to the recruitment of Bax and subsequent cytochrome c release and caspase-3 activation

Springer Netherlands, Dordrecht, pp 273303 Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, Cruz AA, Duijts L, Drazen JM, FitzGerald JM, Fleming LJ, Inoue H, Ko FW, Krishnan JA, Levy ML, Lin J, Mortimer K, Pitrez PM, Sheikh A, Yorgancioglu AA, Boulet LP (2022) Global initiative for asthma strategy 2021: executive summary and rationale for key changes