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Furthermore, by employing the MPTP mouse model to simulate mitochondrial damage and GSH deficiency in PD, we demonstrate that pyridoxine-induced GSH enhancement helpes to reduce the severity of dopaminergic neuron loss and improve some types of mouse locomotion after MPTP administration

After the homologous recombination, Amp-r or Kan-r cassette was excised by adding arabinose to the log phase liquid culture of the EL250 cells with the correctly modified BAC at 0.1% v/v for 1 h at 32C to sufficiently induce Flpe (Fig