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Under a middle GDP growth (SSP2) and middle emissions scenario (RCP4.5), hot and cold death changes are projected to roughly cancel out, and temperature-related mortality stays constant over the century (Carleton et al., 2022, Appendix Figure F.5)

Chen Y, Liao Z, Chen Y, Zang Z, Jin J, Ajani J, Swisher SG , Chang JY, Guerrero T, Jeter M, Allen PK, Cox JD, Komaki R

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The system X C on the cell membrane is a heterodimer consisting of the substrate-specific subunit SLC7A11 (xCT) and the regulatory subunit SLC3A2 ( In many pathological conditions or artificial interventions, increased extracellular glutamate and disrupted xCT structure or function lead to intracellular GSH depletion, thereby inducing ferroptosis (Yadav et al., 2021)