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An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis A systematic review of studies using various cell line models and neurotoxicity induction methods to evaluate the neuroprotective effect of lignans revealed that schisandra lignans show neuroprotective and cognitive enhancement properties through various mechanisms such as anti-apoptosis, inhibiting mRNA and protein expressions of inflammatory mediators, antioxidative actions, and modulating different signalling pathways (18)