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However, the calcium-dependent signaling pathway seemed to contribute to the cytoprotective effect induced by DATS (111)

Br J (Adapted from Sano M, et al

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

They show some positive effects on sleep quality, such as restful sleep, but they dont show that melatonin supplements reverse the cognitive deficits of AD.[ref] One placebo-controlled trial of six months of 2mg time-release melatonin in people with mild to moderate AD did show positive results on cognitive performance compared to placebo