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Women with advanced-stage OC have a five-year survival rate of less than 25%

After transfer of proteins onto nitrocellulose, membranes were Western blotted with the primary antibodies specified below

Mutant lines were developed in Georg Janders lab that lack enzymes involved in nicotine biosynthesis (the reductase A622 and Putrescine methyltransferase PMT), with the A622-deficient line (a622) showing lower nicotine levels and a cold-sensitive, dwarf phenotype leading to the hypothesis that nicotine may be related to plant growth, and therefore, that a nicotine-producing rootstock may rescue the dwarf phenotype