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Evidence for these combinations remains limited to case reports and small case series, but interest is growing

Treatment of MAPT-KI neurons with AD-tau results in the progressive formation of PAD-exposed tau inclusions We performed a seeding time-course experiment in MAPT-KI primary hippocampal neurons and determined that AD-tau seeds the formation of PAD-exposed tau conformations, which are relevant to tauopathies and directly linked to mechanisms of tau-mediated toxicity 28,29,30,31,32,33,34,44,66,67

Moreover, some sequences were also available with different subcellular localizations in the same clade, indicating the possibility of gene duplication events in formation of some APX genes

The mechanistic core of the finding was that Dihexa activated the PI3K/AKT signaling pathway in the brains of the APP/PS1 mice, and that the PI3K inhibitor wortmannin reversed Dihexas anti-inflammatory and anti-apoptotic effects [5]