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Otherwise, MM cells with overexpression of PLR-3 have higher aerobic glycolytic rate, OXPHOS and ATP production by promoting glucose uptake and lactate excretion, enhancing the levels of proteins regulating glycolysis and enzymes in the serine/glycine synthesis pathway [165]

MitoTEMPO, a mitochondrial antioxidant, can directly target mitochondria through the targeted design of antioxidants and related carriers, and can be rapidly transformed into a ubiquinol form with strong antioxidant activity, effectively eliminating ROS and suppressing oxidative stress ( SS-31 is a mitochondria-targeted peptide that selectively localizes to the inner mitochondrial membrane and reduces mtROS accumulation in a dose-dependent manner (Zhao et al., 2004)

10.1016/j.jacc.2013.05.035 73 LiL.FangH.YuY